Tim Williams MA VetMB PhD AFHEA FRCPath DipECVCP MRCVS

EBVS^® European Specialist in Veterinary Clinical Pathology

Associate Professor in Clinical Pathology

Professional history
Tim qualified from the University of Cambridge in 2007, and following a year working in small animal practice in west London, he undertook a PhD in the Feline Research Group at the Royal Veterinary College, London under the supervision of Professor Jonathan Elliott and Professor Harriet Syme. His research focused on feline geriatric medicine and, in particular, the effect of hyperthyroidism on renal function in cats. He received the Society for Comparative Endocrinology award for “Excellence in the Advancement in Veterinary Endocrinology” in 2011 and 2015. Tim joined the department in 2012 as Senior Clinical Training Scholar in Veterinary Clinical Pathology and subsequently became Lecturer in Clinical Pathology in September 2015. He is a Fellow of the Royal College of Pathologists and a Diplomate of the European College of Veterinary Clinical Pathology.

Research

Publications

Key publications:

Recent publications

Lawson JS, Syme HM, Antrobus PR, Karttunen JM, Stewart SE, Karet Frankl FE, Williams TL. Urinary extracellular vesicles as a source of protein based biomarkers in feline chronic kidney disease and hypertension. Journal of Small Animal Practice. (2023) 64: 3-11.

Rooney J, Williams TL, Northcote HM, Karet Frankl FE, Price DRG, Nisbet AJ, Morphew RM, Cantacessi C. Excretory-secretory products from the ‘brown stomach worm’, Teladorsagia circumcincta, exert antimicrobial activity during in vitro growth assays. Parasites and Vectors. (2022) 15: 354.

Loane SC, Thomson JM, Williams TL, McCallum KE. Evaluation of symmetric dimethylarginine in cats with acute kidney injury and chronic kidney disease. Journal of Veterinary Internal Medicine. (2022) 36: 1669-1676.

Thomson JM, Williams TL. Retrospective analysis of association between hepatopathy and DGGR lipase activity in canines. Journal of Veterinary Diagnostic Investigation. (2022) 34(5): 854-858.

Rooney J, Northcote HM, Williams TL, Cortés A, Cantacessi C, Morphew RM. Parasitic helminths and the host microbiome – A missing ‘extracellular vesicle-sized’ link? Trends in Parasitology. (2022) 38(9): 737-747.

Gardner RH, Castillo D, Constantino-Cases F, Williams TL. Can the neutrophil count from hepatic fine needle aspirate cytology be used to diagnose hepatitis in dogs? – a pilot study. Veterinary Clinical Pathology. (2022) 51:237-243.

Castillo D, Williams TL. Stomatocytosis in a beagle and Australian Cattle Dog. Veterinary Clinical Pathology. (2021) 50: 501-506.

Kortum AJ, Bazelle J, Gomez Selgas A, Kent A, Williams TL, Herrtage ME. Clinical findings and outcome following medical treatment in dogs with idiopathic haematuria. Journal of Small Animal Practice. (2021) 62: 850-860.

Bandara Y, Bayton WA, Williams TL, Scase T, Bexfield NH. Histopathological frequency of canine hepatobiliary disease in the United Kingdom. Journal of Small Animal Practice. (2021) 62: 730-736.

Draper ACE, Marshall L, Williams TL, Archer J, Alves L. Retrospective evaluation of hyperproteinorrachia without pleocytosis (albuminocytological dissociation) and survival in dogs. Veterinary Clinical Pathology. (2021) 50: 376-383.

Pena-Ramos J, Barker L, Saiz R, Walker D, Tappin S, Hare C, Roberts M, Williams TL, Bexfield NH. Resting and post-prandial serum bile acid concentrations in dogs with liver disease. Journal of Veterinary Internal Medicine. (2021) 35: 1333-1341.

Sanchez-Redondo S, Hare CHZ, Williams TL. Correlation between cytological findings and histological grade in cutaneous and subcutaneous soft tissue sarcomas in dogs – a pilot study. Veterinary Clinical Pathology. (2021) 50: 236-239.

Kartunnen J, Stewart S, Kalmar L, Grant AJ, Karet Frankl FE, Williams TL. Size-exclusion chromatography separation reveals vesicular and non-vesicular small RNA profiles differ in cell free urine. International Journal of Molecular Sciences. (2021) 22(9): 4881.

Serrano G, Paepe D, Williams TL, Watson PJ. Increased canine specific pancreatic lipase immunoreactivity (Spec cPL) and 1,2-o-dilauryl-rac-glycero-3-glutaricacid-(6’-methylresorufin) ester (DGGR) lipase in dogs with evidence of portal hypertension and normal pancreatic histology – a pilot study. Journal of Veterinary Diagnostic Investigation (2021) 33(3): 548-553.

Wakeling J, Hall T, Williams TL. Correlation of thyroid hormone measurements with thyroid stimulating hormone stimulation test results in radioiodine-treated cats. Journal of Veterinary Internal Medicine. (2020) 34: 2265-2275.

Williams TL, Bastos C, Faria N, Karet Frankl FE. Making urinary extracellular vesicles a clinically tractable source of biomarkers for inherited tubulopathies using a small volume precipitation method: proof of concept. Journal of Nephrology. (2020) 33: 383-386.

Romero-Fernandez N, Ives EJ, Fraser AR, Williams TL, Paul A. Evaluation of the Idexx Procyte Dx® for analysis of canine cerebrospinal fluid. Journal of Small Animal Practice. (2020) 61: 110-115.

Sanchini L, Hare CHZ, Restif O, Williams TL. Evaluation of a salivary urea test strip method for use in dogs. Veterinary Clinical Pathology. (2019) 48(3): 413-418.

Kortum AJ, Cloup EA, Williams TL, Constantino-Casas F, Watson PJ. An investigation into hepatocyte expression and prognostic significance of senescence marker p21 in canine chronic hepatitis. Journal of Veterinary Internal Medicine. (2018) 32(5): 1629-1636.

McCallum KE, Stubbs S, Hope N, Mickleburgh I, Dight D, Tiley L, Williams TL. Detection of morbillivirus and other paramyxoviruses in urine samples of cats with and without chronic kidney disease (CKD) in the United Kingdom. Journal of Veterinary Internal Medicine. (2018) 32(3): 1000-1008.

van den Broek DHN, Geddes RF, Williams TL, Chang YM, Elliott J and Jepson RE. Calcitonin response to naturally occurring ionized hypercalcemia in cats with chronic kidney disease. Journal of Veterinary Internal Medicine. (2018) 32(2): 727-735.

Goodband E, Serrano G, Constantino-Casas F, Archer J, Watson PJ*, Williams TL*. Technical and biological validation of a 1,2-O-Dilauryl-Rac-Glycero Glutaric Acid-(6’-methylresorufin) ester (DGGR) lipase assay for use in canine serum. Veterinary Record Open. (2018) 5: e000270.

Tim Williams MA VetMB PhD AFHEA FRCPath DipECVCP MRCVS