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Fernando Constantino-Casas

Fernand Constantino Casas Pathologist

MVZ PhD FRCPath

RCVS Recognised Specialist in Veterinary Anatomic Pathology

Professional history

Fernando Constantino-Casas graduated with a Bachelor degree in Veterinary Medicine from the National Autonomous University of Mexico (UNAM) in 1985. He was awarded a PhD degree from the University of Cambridge, UK in 1991. Fernando was head of the department of Pathology at the veterinary school in Mexico City from 2001 to 2006. He was then appointed as Senior Lecturer in veterinary pathology, University of Cambridge in 2007 and as University Pathologist in March 2014. He has published 78 papers in peer review journals, 4 chapters and 1 book. He has supervised 14 undergraduate thesis, 8 Master theses and 5 Doctorate theses.

Special interests

Veterinary oncology.
Hepatitis and pancreatitis in dogs and cats.
Infectious diseases.
Syringomyelia in Cavalier King Charles Spaniels.
Pain assessment in sheep.
Please visit Fernando’s research profile for further information.

Recent publications

Hughes JR, Taylor-Brown FE, Greville-Heygate O, Constantino-Casas F, Williams DL, Genain M-A. Multi-modality characteristics of a multifocal choroid plexus carcinoma with bilateral calvarial defects in a dog. Vet Radiol Ultrasound. Accepted, February 2019.

McCallum K, Constantino-Casas F, Cullen J, Warland J, Swales H, Linghley N. Kortum A, Sterritt A, Cogan T, Watson P. Hepatic leptospiral infections in dogs without obvious renal involvement. J Vet Inter Med. 2019:33(1):141-150.

Wong K, Van der Weyden L, Schott C, Foote A, Constantino-Casas F, Smith S, Dobson J, Murchison E, Wu H, Yeh I, Fullen D, Joseph N, Bastian B, Patel R, Martincorena I, Robles-Espinoza R, Iyer V, Arends M, Brenn T, Harms P, Wood G, Adams A, Kuijjer M. Cross-species genomic landscape comparison of human mucosal melanoma with canine oral and equine melanoma. Nature Communications. 2019:10(1):353-366.

Erich SA, Constantino-Casas F, Dobson JM, Teske E. Morphological distinction of histocytic sarcoma from other tumor types in Bernese Mountain Dogs and Flat coated retrievers. In Vivo. 2018;32(1);7-17.

Mueller S, Engleitner T, Maresch R, Zukowska M, Lange S, Kaltenbacher T, Konukiewitz B, Ollinger R, Zwiebel M, Strong A, Yen H-Y, Banerjee G, Louzada S, Fu B, Seidler B,  Gotzfried J, Schuck K, Hassan Z, Arbeiter A, Schomhuber N, Klein S, Veltkamp C, Friedrich M, Rad L, Barenboim M, Ziegenhain C, Hess J, Dovey OM, Eser S, Parekh S, Constantino-Casas F, De la Rosa J, Sierra MI, Fraga M, Mayerle J, Kloppel G, Cardinanos J, Liu P, Vassiliou G, Weichert W, Steiger K, Enard W, Schmid RR, …. Rad R. Evolutionary trajectories and KRAS gene dosage define pancreatic cancer phenotypes. Nature. 01 February 2018;554:62-68.

Popis MC, Wagner RE. Constantino-Casas F, Blanco S. Frye M. Considerations for skin carcinogenesis experiments using inducible transgenic mouse models. BMC Res Notes. 2018;11:67.

Goodband E, Serrano G, Constantino-Casas F, Archer J, Watson P, Williams T. Validation of a commonly used 1,2-O=Dilauryl-Rac-Glycero Glutaric Acid-(6’-methylresorufin) ester lipase assay for diagnosis of canine pancreatitis. Vet Rec Open. 2018;5:1-5.

Kortum AJ, Cloup EA, Williams TL, Constantino-Casas F, Watson PJ. Hepatocyte expression and prognostic importance of senescence marker p21 in liver histopathology samples from dogs with chronic hepatitis. J Vet Intern Med. 2018;32(5):1629-1636.

Erich Suzzanne A., Constantino-Casas F, Dobson JM & Teske E. Morphological distinction of histocytic sarcoma from other tumor types in Bernese Mountain Dogs and Flat coated retrievers. In Vivo. In press 2017.

Giuliano A, Dos Santos Horta R, Constantino-Casas F, Hoather T, and Dobson JM. Expression of Fibroblast Activating Protein and Correlation with Histological Grade, Mitotic Index and Ki67 Expression in Canine Mast Cell tumours. J Comp Path. 2017;156(1), 14-20.

Garcia LJ, Gonzalez DG, Prado OM, Macedo JR, Ramirez R, Martinez J, Barrios HB. Lopez A, Constantino F.  Identification of non-tuberculous mycobacteria isolated from opossum (Didelphis virginiana) lymph nodes and charactierisation of lesions. Australian Journal of Veterinary Science, 2017;49, 199-203.

Hughes K, Constantino-Casas F, Haverson V, Philp S. Pathology in practice: Yersinia pseudotuberculosis infection in three captive Egyptian fruit bats (Rousettus aegyptiacus). Journal of the American Veterinary Medical Association. In press 2016.

McLennan KM, Corke MJ, Rebelo C, Broom D, Constantino-Casas F. Development of a facial expression scale using footrot and mastitis as models of pain in sheep. Applied Animal Behaviour Science, 2016;176, 19-26.

Kent ACC, Constantino-Casas F, Rusbridge C, Corcoran BM, Carter M, Leadger T, Watson PJ. Prevalence of pancreatic, hepatic and renal microscopic lesions in post-mortem samples from cavalier King Charles spaniels. Journal of Small Animal Practice, 2016;57, 188-193.

Dobson JM, Hoather T, Constantino-Casas F. Flat-Coated Retriever dog tumour survey 25 years. Veterinary Times;2016;11, 14-18.

Giuliano A, Swift R, Arthurs A, Marote G, Abramo F, McKay J, Thomson C, Beltran M, Millar M, Priestnall S, Dobson JM, Constantino-Casas F, Petrou T, McGonnell IM, Davies AJ, Weetman M, Garden OA, Masters JR, Thrasivoulou C, Ahmed A. Quantitative Expression and Co-localization of Wnt signalling related proteins in Feline Squamous cell carcinoma. PLoS ONE;2016;25, 1-17.

Kent A, Constantino-Casas F, Herrtage ME. Naturally occuring acquired primary hypothyroidism in a cat due to lymphocytic thyroiditis. Veterinary Record Case Reports, 2016;4(1), doi:10.1136/vetreccr- 2015-000282

Hughes K, Archer J, Constantino-Casas F, Wozniakowski G, Baigent S. Diagnostic Investigation of Marek’s disease in a turkey. Veterinary Record Case Reports. 2016;4(1),  doi:10.1136/ vetreccr-2016-000291.

Rad R, Rad L, Wang W, Strong A, Ponstingl A, Bronner IF, Mayho M, Steiger K, Weber J, Hieber M, Veltkamp C, Eser S, Geumann U, Ollinger R, Zukowska M, Barenboim M, Maresch R, Caldinanos J, Friedrich M, Varela I, Constantino-Casas F, Sarver A, ten Hoeve J, Prosser H, et al. A conditional PiggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer. Nature Genetics, 2015;47(1), 47-56.

Salgüero R, Demetriou J, Constantino-Casas F, Herrtage M. Hypertrophic Osteopathy in a cat with a concurrent injection site sarcoma. Journal of Feline Medicine and Surgery, Open reports, 2015; DOI:10.1177/2055116915593968

McLennan KM, Skillings EA, Rebelo CJB, Corke MJ, Pires Moreira MA, Morton AJ, Constantino-Casas F. Technical validation of an automatic recording system to assess behavioural activity level in sheep (Ovis aries). Small Ruminant Research, 2015;127, 92-96.

Marcinowska A, Constantino-Casas F, Dobson JM. Histiocytic sarcoma in a flat coated retriever with central and peripheral nervous system sarcomatosis. Veterinary Record Case Reports 2014;2 e000029. DOI: 10.1136/vetreccr-2013-000029.

Rupp A, Ives E, Rudorf H, Constantino-Casas F. Sciatic T-cell neurolymphomatosis in a dog. Veterinary Record Case Reports, 2014; 2 e000050. doi:10.1136/vetreccr-2014-000050