skip to primary navigationskip to content
 

Kate Hughes

Kate HUGHES Pathology

BSc (Hons) BVSc PhD FRCPath DipACVP MRCVS

Professional history

Kate undertook her veterinary training at the University of Liverpool, where she graduated with a BVSc awarded with distinction and a first class intercalated BSc (Hons). Following graduation, she worked as a clinical veterinarian prior to undertaking a residency in veterinary anatomic pathology at the University of Cambridge. During her Wellcome Trust Research Training Fellowship (PhD studies) Kate was awarded the 2012 Royal College of Pathologists gold research medal for trainees. Kate is a Fellow of the Royal College of Pathologists, a Diplomate of the American College of Veterinary Pathologists and a Royal College of Veterinary Surgeons Specialist in Veterinary Pathology.


Special interests

Mammary gland biology, including both mammary tumours arising in
companion animals, and mastitis.

Companion animal neoplasia.

Pancreatic microenvironment in canine and feline diabetes

Rabbit pathology.

 

Current research

Kate studies mammary gland biology, focussing on interactions between different cell types within the mammary gland, both in tumourigenesis and in mastitis. A second research strand focuses on the pancreatic microenvironment in canine and feline diabetes. As a veterinary pathologist and active diagnostician she also has wider research interests in diagnostic veterinary pathology, including companion animal neoplasia and equine and rabbit pathology. Please visit Kate’s research profile for further information.

 

Recent publications

Stewart TA, Hughes K, Stevenson AJ, Marino N, Ju AL, Morehead M, Davis FM. Mammary mechanobiology: PIEZO1 mechanically-activated ion channels in lactation and involution. bioRxiv 649038; doi: https://doi.org/10.1101/649038

Davison LJ, Wallace MD, Preece C, Hughes K, Todd JA, Davies B, O’ Callaghan CA. Dexi disruption depletes gut microbial metabolites and accelerates autoimmune diabetes. bioRxiv 393421; doi: https://doi.org/10.1101/393421

Hare C, Archer J, Cloup E, Genain M, Hughes K, McCallum K, Alves L. Myoclonus and hypercalcemia in a dog with poorly differentiated lymphoproliferative neoplasia. J Vet Intern Med. 2019; 33: 856-861.

Hughes K*, Watson CJ. Sinus-like dilatations of the mammary milk ducts, Ki67 expression, and CD3-positive T lymphocyte infiltration, in the mammary gland of wild European rabbits during pregnancy and lactation. J Anat. 2018; 233: 266-273.

Hughes K*, Watson CJ. The mammary microenvironment in mastitis in humans, dairy ruminants, rabbits and rodents: A One Health focus. J Mammary Gland Biol Neoplasia. 2018; 23 (1-2): 27-41.

Mangolini M, Goette F, Moore A, Ammon T, Lutzny-Geier G, Klein-Hitpass L, Williamson J, Lehner P, Dürig J, Moellemann M, Raso-Barnett L, Hughes K, Santoro A, Mendez-Ferrer S, Oostendorp R, Zimber-Strobl U, Peschel C, Hodson D, Schmidt-Supprian M, Ringshausen I, Oelsner M. Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia. Nat Commun. 2018; 9, article number: 3839.

Hughes K*, Constantino-Casas F, Haverson V, Philp S. Pathology in practice: Yersinia pseudotuberculosis infection in three captive Egyptian fruit bats (Rousettus aegyptiacus). J Am Vet Med Assoc. 2018; 253 (7): 865-868.

Hughes K*, Watson CJ*. The multifaceted role of STAT3 in mammary gland involution and breast cancer. Int J Mol Sci. 2018; 19 (6): 1695.

Hughes K*, Borman AM. Adiaspiromycosis in a wild European rabbit, and a review of the literature. J Vet Diagn Invest. 2018; 30 (4): 614–618.

Turner AD, Dhanji-Rapkova M, Dean K, Milligan S, Hamilton M, Thomas J, Poole C, Haycock J, Spelman-Marriott J, Watson A, Hughes K, Marr B, Dixon A, Coates L. Fatal canine intoxications linked to the presence of saxitoxins in stranded marine organisms following winter storm activity. Toxins. 2018; 10 (3): 94.

Kucia-Tran J, Tulkki V, Smith S, Scarpini CG, Paez-Ribes M, Feeney M, Wallberg M, Hughes K, Caffarel MM, Coleman N. Anti-oncostatin M antibody inhibits the pro-malignant effects of oncostatin M receptor overexpression in squamous cell carcinoma. J Pathol. 2018; 244 (3): 283-295.

Barbon A, Cowen R, Knott C, Hughes K, Allinson K, Williams C, Routh A. Neoplasia in three aye ayes (Daubentonia madagascariensis). J Comp Pathol. 2018; 159: 16-20.

Hughes K*, Scott VHL, Blanck M, Barnett TP, Spanner Kristiansen J, Foote AK. Equine renal hemangiosarcoma: Clinical presentation, pathological features, and pSTAT3 expression. J Vet Diagn Invest. 2018; 30 (2): 268-274.

Ives EJ, Vanhaesebrouck AE, Hughes K. Metastatic adenocarcinoma with osseous metaplasia in the hind limb musculature of a cat. J Small Anim Pract. 2018; 59 (2): 133.

Scott VHL*, Hughes K*. Diagnosis of equine penile and preputial masses: A clinical and pathological perspective. Equine Vet Educ. 2017; 29 (1): 10-14.

Kucia-Tran J, Tulkki V, Smith S, Scarpini CG, Paez-Ribes M, Feeney M, Wallberg M, Hughes K, Caffarel MM, Coleman N. Anti-oncostatin M antibody inhibits the pro-malignant effects of oncostatin M receptor overexpression in squamous cell carcinoma. J Pathol. 2017; In press.

Hughes K, Scott VHL, Blanck M, Barnett TP, Spanner Kristiansen J, Foote AK. Equine renal hemangiosarcoma: Clinical presentation, pathological features, and pSTAT3 expression. J Vet Diagn Invest. 2017; Epub ahead of print. DOI: 10.1177/1040638717745575

Ives EJ, Vanhaesebrouck AE, Hughes K. Metastatic adenocarcinoma with osseous metaplasia in the hind limb musculature of a cat. Journal of Small Animal Practice. 2017; In press.

Scott VHL, Hughes K. Diagnosis of equine penile and preputial masses: A clinical and pathological perspective. Equine Veterinary Education. 2017; 29 (1): 10-14

Hughes K, Constantino-Casas F, Haverson V, Philp S. Pathology in Practice: Yersinia pseudotuberculosis infection in three captive Egyptian fruit bats (Rousettus aegyptiacus). Journal of the American Veterinary Medical Association. 2016; In press.

Hughes K, Blanck M, Pensa S, Watson CJ. Stat3 modulates chloride channel accessory protein expression in normal and neoplastic mammary tissue. Cell Death & Disease. 2016; 7 (10), e2398.

Kucia-Tran J, Tulkki V, Smith S, Scarpini C, Hughes K, Araujo A, Yan K, Botthof J, Pérez-Gómez E, Quintanilla M, Cuschieri K, Munoz-Caffarel M, Coleman N. Over-expression of the oncostatin-M receptor in cervical squamous cell carcinoma is associated with epithelial-mesenchymal transition and increased metastasis. Br J Cancer. 2016; 115: 212–222.

Malcolm T, Villarese P, Fairbairn C, Lamant L, Trinquand A, Hook C, Amos Burke G, Brugières L, Hughes K, Payet D, Merkel O, Schiefer A, Ashankyty I, Mian S, Wasik M, Turner M, Kenner L, Asnafi V, Macintyre E, Turner SD. Anaplastic large cell lymphoma arises in thymocytes and requires transient T cell receptor expression for thymic egress. Nat Commun. 2016; 7, article number: 10087.

Hughes K*, Archer J, Constantino-Casas F, Wozniakowski G, Baigent S. Diagnostic investigation of Marek’s disease in a turkey. Vet Rec Case Rep. 2016; 4, article number: 00291

Hughes K*, Scase TJ, Foote, AK. Estrogen receptor and Signal Transducer and Activator of Transcription 3 expression in equine mammary tumors. Vet Path. 2015; 52 (4): 631-634.

Man SM, Ekpenyong A, Tourlomousis P, Achouri S, Cammarota E, Hughes K, Rizzo A, Ng G, Wright JA, Cicuta P, Guck JR, Bryant CE. Actin polymerization as a key innate immune effector mechanism to control Salmonella infection. Proc Natl Acad Sci USA. 2014; 111 (49): 17588-93.

Watson C, Hughes K. Breast cancer: the menacing face of Janus kinase. Cell Death Differ. 2014; 21 (2): 185-6.