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Kate Hughes

Kate HUGHES Pathology


Professional history

Kate undertook her veterinary training at the University of Liverpool, where she graduated with a BVSc awarded with distinction and a first class intercalated BSc (Hons). Following graduation, she worked as a clinical veterinarian prior to undertaking a residency in veterinary anatomic pathology at the University of Cambridge. During her Wellcome Trust Research Training Fellowship (PhD studies) Kate was awarded the 2012 Royal College of Pathologists gold research medal for trainees. Kate is a Fellow of the Royal College of Pathologists and is a Diplomate of the American College of Veterinary Pathologists.

Special interests

Mammary gland biology, including both mammary tumours arising in
companion animals, and mastitis.

Companion animal neoplasia.

Equine and rabbit pathology.

Current research

Kate studies mammary gland biology, focussing on interactions between different cell types within the mammary gland, both in tumourigenesis and in mastitis. As a veterinary pathologist and active diagnostician she also has wider research interests in diagnostic veterinary pathology, including companion animal neoplasia and equine and rabbit pathology. Please visit Kate’s research profile for further information.

Recent publications

Kucia-Tran J, Tulkki V, Smith S, Scarpini CG, Paez-Ribes M, Feeney M, Wallberg M, Hughes K, Caffarel MM, Coleman N. Anti-oncostatin M antibody inhibits the pro-malignant effects of oncostatin M receptor overexpression in squamous cell carcinoma. J Pathol. 2017; In press.

Hughes K, Scott VHL, Blanck M, Barnett TP, Spanner Kristiansen J, Foote AK. Equine renal hemangiosarcoma: Clinical presentation, pathological features, and pSTAT3 expression. J Vet Diagn Invest. 2017; Epub ahead of print. DOI: 10.1177/1040638717745575

Ives EJ, Vanhaesebrouck AE, Hughes K. Metastatic adenocarcinoma with osseous metaplasia in the hind limb musculature of a cat. Journal of Small Animal Practice. 2017; In press.

Scott VHL, Hughes K. Diagnosis of equine penile and preputial masses: A clinical and pathological perspective. Equine Veterinary Education. 2017; 29 (1): 10-14

Hughes K, Constantino-Casas F, Haverson V, Philp S. Pathology in Practice: Yersinia pseudotuberculosis infection in three captive Egyptian fruit bats (Rousettus aegyptiacus). Journal of the American Veterinary Medical Association. 2016; In press.

Hughes K, Blanck M, Pensa S, Watson CJ. Stat3 modulates chloride channel accessory protein expression in normal and neoplastic mammary tissue. Cell Death & Disease. 2016; 7 (10), e2398.

Kucia-Tran J, Tulkki V, Smith S, Scarpini C, Hughes K, Araujo A, Yan K, Botthof J, Pérez-Gómez E, Quintanilla M, Cuschieri K, Munoz-Caffarel M, Coleman N. Over-expression of the oncostatin-M receptor in cervical squamous cell carcinoma is associated with epithelial-mesenchymal transition and increased metastasis. Br J Cancer. 2016; 115: 212–222.

Malcolm T, Villarese P, Fairbairn C, Lamant L, Trinquand A, Hook C, Amos Burke G, Brugières L, Hughes K, Payet D, Merkel O, Schiefer A, Ashankyty I, Mian S, Wasik M, Turner M, Kenner L, Asnafi V, Macintyre E, Turner SD. Anaplastic large cell lymphoma arises in thymocytes and requires transient T cell receptor expression for thymic egress. Nat Commun. 2016; 7, article number: 10087.

Hughes K*, Archer J, Constantino-Casas F, Wozniakowski G, Baigent S. Diagnostic investigation of Marek’s disease in a turkey. Vet Rec Case Rep. 2016; 4, article number: 00291

Hughes K*, Scase TJ, Foote, AK. Estrogen receptor and Signal Transducer and Activator of Transcription 3 expression in equine mammary tumors. Vet Path. 2015; 52 (4): 631-634.

Man SM, Ekpenyong A, Tourlomousis P, Achouri S, Cammarota E, Hughes K, Rizzo A, Ng G, Wright JA, Cicuta P, Guck JR, Bryant CE. Actin polymerization as a key innate immune effector mechanism to control Salmonella infection. Proc Natl Acad Sci USA. 2014; 111 (49): 17588-93.

Watson C, Hughes K. Breast cancer: the menacing face of Janus kinase. Cell Death Differ. 2014; 21 (2): 185-6.

Hughes K, Wickenden J, Allen J, Watson C. Conditional deletion of Stat3 in mammary epithelium impairs the acute phase response and modulates immune cell numbers during post-lactational regression. J Pathol. 2012; 227 (1): 106–117.

Hughes K*, Dobson J. Prognostic histopathological and molecular markers in feline mammary neoplasia. The Veterinary Journal. 2012; 194 (1):19-26.

Hughes K, Watson C. The spectrum of Stat functions in mammary gland development. JAK-STAT. 2012; 1 (3): 151–158.

Hughes K, Watson C. The role of Stat3 in mammary gland involution: Cell death regulator and modulator of inflammation. Horm Mol Biol Clin Invest. 2012; 10 (1): 211–215.